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Your doctor or pharmacist if you are allergic to it or to sulfa drugs. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. If you are already taking Celebrex, it is important to keep taking it as instructed by your doctor. If you are already taking Celebrex, use the lowest dose possible for the shortest possible time necessary to relieve your symptoms. Celecoxib does not interfere with the clotting of blood. Fluconazole increases the concentration of Celecoxib in the liver. Celebrex works by blocking the action of a substance in the body by inhibiting the breakdown of Celecoxib in the liver. When the benefits outweigh the potential risk to the fetus.
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