Ask your health care provider any questions you may have about how to use Fluconazole. Fluconazole is commonly used for prophylaxis in transplant patients. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Fluconazole is commonly used for prophylaxis in transplant patients. Fluconazole is a very widely used antifungal agent. Diflucan is usually taken by mouth as a one-time only dose with or without food or as directed by your doctor. Diflucan comes as a tablet and liquid to take by mouth usually taken once a day.
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