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The acute treatment of migraine headaches has not been studied. Topamax is used to prevent migraine headaches. It is especially important that your doctor knows if you are taking digoxin, contraceptive pills, amitriptyline, or anti-epileptic drugs, such as anxiety, rapid speech, or thoughts of suicide. Drink some liquid after swallowing Topiramate to make sure the entire drug is swallowed. There is anecdotal evidence enough to prescribe them for this use. Treatment must be started under specialist care and continued under the supervision of a specialist. The same active ingredient. There is anecdotal evidence enough to prescribe them for this use. Topiramate can help reduce the frequency, severity, and duration of migraines.