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Synthroid is the number one prescribed treatment for thyroid disease, in conditions where the thyroid gland. Synthroid is the number one prescribed treatment for thyroid disease, in conditions where the thyroid gland. Differences of only a few micrograms of Synthroid can make a large difference in how you feel. Synthroid is long acting and comes in a wide variety of medications. You may have an allergic reaction such as a rash or hives. Common side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever.
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